The causes of primary bone neoplasms in general are still unknown. Persons suffering from chronic inflammatory diseases of the bones (Paget’s disease), are at higher risk of developing osteogenous sarcoma in adulthood or old age, but the disease occurs in a very small number of people.

Secondary bone tumors is always evolving as a result of primary tumors in other organs. Sometimes the primary tumor could be the first manifestation of the primary cancers, running completely asymptomatic.