Treatment depends on the localization of primary tumor and on bone cancer symptoms. For example, if it develops in the chest, secondary tumors of the bone is likely to treat by methods used for breast cancer, such as hormone therapy and chemotherapy.

Many bone tumors, especially the secondary, are active in the cells called osteoclasts that lead to the destruction of bone. The drugs, known as bisphosphonates, can give a very good effect, reducing the activity of osteoclasts and thus slowing or weakening the destruction of bones.

Understanding and being informed on available therapies, and cancer treatment centers can be crucial.